Curcumin Inhibits CD4+ T Cell Activation, but Augments CD69 Expression and TGF-β1-Mediated Generation of Regulatory T Cells at Late Phase
Background Curcumin is a promising candidate for a natural medicinal agent to treat chronic
inflammatory diseases. Although CD4+ T cells have been implicated in the pathogenesis of
chronic inflammation, whether curcumin directly regulates CD4+ T cells has not been
definitively established. Here, we showed curcumin-mediated regulation of CD2/CD3/CD28-
initiated CD4+ T cell activation in vitro. Methodology/Principal Findings Primary human
CD4+ T cells were stimulated with anti-CD2/CD3/CD28 antibody-coated beads as an in vitro …
inflammatory diseases. Although CD4+ T cells have been implicated in the pathogenesis of
chronic inflammation, whether curcumin directly regulates CD4+ T cells has not been
definitively established. Here, we showed curcumin-mediated regulation of CD2/CD3/CD28-
initiated CD4+ T cell activation in vitro. Methodology/Principal Findings Primary human
CD4+ T cells were stimulated with anti-CD2/CD3/CD28 antibody-coated beads as an in vitro …
Curcumin inhibits CD4+ T cell activation, but augments CD69 expression and TGF-β1-mediated generation of regulatory T cells at late phase.
KGR Kim GiRak, JMS Jang MiSeon… - 2013 - cabidigitallibrary.org
Background: Curcumin is a promising candidate for a natural medicinal agent to treat
chronic inflammatory diseases. Although CD4+ T cells have been implicated in the
pathogenesis of chronic inflammation, whether curcumin directly regulates CD4+ T cells has
not been definitively established. Here, we showed curcumin-mediated regulation of
CD2/CD3/CD28-initiated CD4+ T cell activation in vitro. Methodology/Principal Findings:
Primary human CD4+ T cells were stimulated with anti-CD2/CD3/CD28 antibody-coated …
chronic inflammatory diseases. Although CD4+ T cells have been implicated in the
pathogenesis of chronic inflammation, whether curcumin directly regulates CD4+ T cells has
not been definitively established. Here, we showed curcumin-mediated regulation of
CD2/CD3/CD28-initiated CD4+ T cell activation in vitro. Methodology/Principal Findings:
Primary human CD4+ T cells were stimulated with anti-CD2/CD3/CD28 antibody-coated …
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