The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant
factor accounting for age-associated changes in non-renal drug clearance. The group of
drug-metabolising enzymes most studied are the cytochrome P450 (CYP) superfamily. The
CYP3A subfamily is the most abundant group of CYP enzymes in the liver and consists of at
least 3 isoforms: CYP3A4, 3A5 and 3A7. Many drugs are mainly metabolised by the CYP3A …

Maturation of organ systems during fetal life and childhood exerts a profound effect on drug
disposition. The maturation of drug-metabolizing enzymes is probably the predominant
factor accounting for age-associated changes in non-renal drug clearance. Tbe group of
drug-metabolizing enzymes most studied is the cytochrome P-450 (CYP) superfamily. The
CYP3A subfamily is the most abundant group of CYP enzymes in the liver and consists of at
least 3 isoforms: CYP3A4, 3A5 and 3A 7. Many drugs are mainly metabolized by the CYP3A …