This study was conducted to determine the level of anxiety and eHealth literacy and related factors among physicians and nurses working in inpatient and intensive care units where COVID-19 patients were cared for during the pandemic. This descriptive study was conducted with 161 physician and nurse working in inpatient and intensive care units. A p-value of< 0.05 was considered statistically significant. The mean scores of the Coronavirus Anxiety Scale and eHealth Literacy Scale (eHEALS) of physicians and nurses were 2.74±3.57 and 28.72±7.74, respectively. It was found that physicians and nurses who desired psychological support had high anxiety scores but low scores on the eHEALS. Anxiety increased the longer one engaged in viewing/reading information or news about the pandemic. During the pandemic outbreak, it is crucial to regularly inform physicians and nurses about the pandemic through appropriate sources and provide them with the necessary psychological support after determining their level of anxiety.