… aureus to induce miR-15b-5p in human ex vivo acute wounds and confirmed down-regulation …
Unresolved suboptimal inflammatory response was also found in another type of chronic …

… Venous leg ulcers, diabetic foot ulcers, and pressure ulcers … Promoting inflammatory profile
to the one resembling an acute wound … inflammatory process by delineating the role of each …

… inflammation in chronic wounds is present at suboptimal levels … compared to normal acute
wound inflammatory response 6,7 . … a Representative image of a diabetic foot ulcer (DFU). b …

… inflammation present in non-healing VLU is at a suboptimal level … with the normal acute
wound inflammatory response.44 … aureus induced miR-15b-5p, subsequently repressing DNA …

… in untreated acute wounds and chronic wounds treated with … important mediator of immune
responses and wound healing. … Diabetes and nonhealing diabetic foot ulcers are the leading …

… of miR-15b-5p and led to a sustained inflammatory response … in acute wounds. Various
pathogens form biofilms in chronic … regulation, yet the effect is suboptimal. Because chronic …

… Chronic wounds are characterized by an extended, suboptimal inflammatory response, with
… the needed shift from a non-healing wound into an acute wound with healing properties. …

… suboptimal efficacy 6,17 . For example, recombinant human VEGF-A was in Phase II clinical
trials, but improvement of diabetic foot ulcer … wound healing process is very tightly regulated …

… an essential role in Th1-type immune response against cancer, a condition where cells in
a … at the wound ite, suggesting that these pathways regulate the wound response. Hippo …