[HTML][HTML] DICER1 somatic mutations strongly impair miRNA processing even in benign thyroid lesions
AM Poma, V Condello, M Denaro, L Torregrossa… - Oncotarget, 2019 - ncbi.nlm.nih.gov
The alteration of miRNA processing is a driver event in several tumors including thyroid
cancer. In particular, somatic DICER1 mutations, reported in follicular-patterned lesions, are
shared by benign as well as malignant tumors. In the present study, we investigated the
effects of alterations in the miRNA processing genes on the miRNA profile.
cancer. In particular, somatic DICER1 mutations, reported in follicular-patterned lesions, are
shared by benign as well as malignant tumors. In the present study, we investigated the
effects of alterations in the miRNA processing genes on the miRNA profile.
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