DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å
Y Liu, YO Olanrewaju, X Zhang, X Cheng - Biochemistry, 2013 - ACS Publications
The Zfp57 gene encodes a KRAB (Krüppel-associated box) domain-containing C2H2 zinc
finger transcription factor that is expressed in early development. Zfp57 protein recognizes
methylated CpG dinucleotide within G CG GCA elements at multiple imprinting control
regions. In the previously determined structure of the mouse Zfp57 DNA-binding domain in
complex with DNA containing 5-methylcytosine (5mC), the side chains of Arg178 and
Glu182 contact the methyl group via hydrophobic and van der Waals interactions. We …
finger transcription factor that is expressed in early development. Zfp57 protein recognizes
methylated CpG dinucleotide within G CG GCA elements at multiple imprinting control
regions. In the previously determined structure of the mouse Zfp57 DNA-binding domain in
complex with DNA containing 5-methylcytosine (5mC), the side chains of Arg178 and
Glu182 contact the methyl group via hydrophobic and van der Waals interactions. We …
[引用][C] DNA Recognition of 5-Carboxylcytosine by a Zfp57 Mutant at an Atomic Resolution of 0.97 Å
L Yiwei, OY Olatunde, Z Xing, C Xiaodong - 2013
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