[HTML][HTML] DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma
Recently discovered DNAJB1-PRKACA oncogenic fusions have been considered
diagnostic for fibrolamellar hepatocellular carcinoma. In this study, we describe six
pancreatobiliary neoplasms with PRKACA fusions, five of which harbor the DNAJB1-
PRKACA fusion. All neoplasms were subjected to a hybridization capture-based next-
generation sequencing assay (MSK-IMPACT), which enables the identification of sequence
mutations, copy number alterations, and selected structural rearrangements involving≥ 410 …
diagnostic for fibrolamellar hepatocellular carcinoma. In this study, we describe six
pancreatobiliary neoplasms with PRKACA fusions, five of which harbor the DNAJB1-
PRKACA fusion. All neoplasms were subjected to a hybridization capture-based next-
generation sequencing assay (MSK-IMPACT), which enables the identification of sequence
mutations, copy number alterations, and selected structural rearrangements involving≥ 410 …