Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial

ME Nassif, SL Windsor, F Tang, Y Khariton, M Husain… - Circulation, 2019 - Am Heart Assoc
patients treated with dapagliflozin experienced clinically meaningful improvements in heart
failure–related symptoms, functional statuspatients with and without type 2 diabetes mellitus. …

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction

DHF Trial - Circulation, 2019 - utsouthwestern.elsevierpure.com
… : In patients with heart failure and reduced ejection fraction, use of dapagliflozin over 12
weeks did not affect mean NT-proBNP but increased the proportion of patients experiencing …

Effects of dapagliflozin on symptoms, function, and quality of life in patients with heart failure and reduced ejection fraction: results from the DAPA-HF trial

MN Kosiborod, PS Jhund, KF Docherty, M Diez… - Circulation, 2020 - Am Heart Assoc
… , and improved symptoms in patients with heart failure and … the effects of dapagliflozin on a
broad range of health status outcomes… symptom burden, functional status, and quality of life in …

Effects of dapagliflozin on biomarkers, symptoms and functional status in patients with heart failure with reduced ejection fraction with and without diabetes-the Define …

M Kosiborod, M Nassif, S Windsor, F Tang… - Journal of Cardiac …, 2019 - Elsevier
… -2i in patients with established HFrEF with and without T2D. It will assess whether the …
dapagliflozin improves HF biomarkers, symptoms and functional status in this high-risk patient

Metabolic effects of the SGLT2 inhibitor dapagliflozin in heart failure across the spectrum of ejection fraction

S Selvaraj, S Patel, AJ Sauer, RW McGarrah… - Circulation: Heart …, 2024 - ahajournals.org
… and Functional Status in Patients With … effect of dapagliflozin on biomarkers of fatty acid
metabolism was consistent across left ventricular ejection fraction (LVEF), but the ketogenic effect

Metabolomic profiling of the effects of dapagliflozin in heart failure with reduced ejection fraction: DEFINE-HF

S Selvaraj, Z Fu, P Jones, LC Kwee, SL Windsor… - Circulation, 2022 - Am Heart Assoc
… and Functional Status in Patients With HF With Reduced Ejection Fraction)… effects of
dapagliflozin on HF disease-specific biomarkers (NT-proBNP) and health status (symptoms, function

Association between Dapagliflozin, Cardiac Biomarkers and Cardiac Remodeling in Patients with Diabetes Mellitus and Heart Failure

A Xanthopoulos, N Katsiadas, S Skoularigkis… - Life, 2023 - mdpi.com
… and structure; however, less is known about dapagliflozin. The purpose of the current work …
of dapagliflozin and cardiac biomarkers as well as the cardiac structure in a cohort of patients

Dapagliflozin improves heart failure symptoms and physical limitations across the full range of ejection fraction: pooled patient-level analysis from DEFINE-HF and …

ME Nassif, SL Windsor, K Gosch… - Circulation: Heart …, 2023 - Am Heart Assoc
… -HF (Effects of Dapagliflozin on Biomarkers, Symptoms and Functional Status in Patients
With Preserved Ejection Fraction Heart Failure) trials, dapagliflozin has been previously …

… of Dapagliflozin in Patients with Heart Failure with Reduced Ejection Fraction: Multicentre Retrospective Study on Echocardiographic Parameters and Biomarkers of …

I Battistoni, G Pongetti, E Falchetti, I Giannini… - Journal of Clinical …, 2024 - mdpi.com
… with heart failure and reduced ejection fraction (HFrEF). … of dapagliflozin in a real-world
population of HFrEF patients … included HFrEF patients who were initiated on dapagliflozin therapy …

Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes

JL Januzzi Jr, J Butler, P Jarolim, N Sattar… - Journal of the American …, 2017 - jacc.org
… In another small study of 75 patients with T2DM randomized to dapagliflozin, … for T2DM
may exert favorable cardiovascular effects. Concentrations of each biomarker measured in this …