… We detected a high molecular heterogeneity between pediatric and adult AML at the stem
cell level. LSC populations from both entities shared 71 suppressed transcripts, but only three …

… considerably improved prognostication of pediatric AML (pedAML) patients, … transcriptome
of AML subpopulations, eg leukemic stem cells (LSCs), might result in a better understanding …

… As pediatric and adult AML represent two genetically distinct diseases,32 we wondered if
this heterogeneity is also reflected in the stem cell transcriptome. To this end, we re-analyzed …

… of the transcriptome to characterize transcriptional dysregulation in … I will provide a review
of the molecular characteristics that separates pediatric AML from adult AML, as well as our …

… Transcriptomic profiling of AML has significantly improved our understanding of tumor
hierarchical structure and led to the identification of novel cell types, leukemic stem cells (LSCs), …

… transcriptomic landscape of pediatric MPAL and demonstrated that B/My and T/My MPAL have
distinct scRNAseq profiles from each other, AML… Analyzing the biology and understanding …

… To gain a deeper understanding of the mechanisms … the heterogeneity between AML
subtypes and within Dx-Re pairs, we profiled the exome, gene fusions and single cell transcriptome …

… and the most heterogeneous subgroup was AML with normal … adult AML samples triggered
the research of childhood AML. … completely changed our understanding of biology and at …

… [6], the enormous molecular heterogeneity of the disease was … may help readers in
understanding the importance of these … 10X Genomics for genomic and transcriptomic analyses at …

… polymorphisms (SNPs), revealing the heterogeneity and complexity of AML[1]. This genomic
… of understanding, which is not readily attainable by examining more molecular diverse AML …