… In conclusion, here we have described the timeline of initial copy number alterations observed
in MM and confirmed their early occurrence using data from a unique early stage plasma …

… Our results also highlight that for both HMM and NHMM groups the major copy number …
MGUS patients progress to MM. Here, we describe the time line of initial copy number alterations …

… (ie, copy number abnormalities, CNA) in multiple myeloma. Of note, more than 60% of … In
the last 8 years, our understanding of the clinical and biological landscape of multiple myeloma …

… To advance our understanding of MM evolution mechanisms, … mechanisms that shape
their history, we performed whole-… of clonal and subclonal copy number alterations (CNAs) for …

… The use of NGS in MM has greatly expanded our understanding of the genetic diversity,
crucial mutations, and evolution of the disease. Several large-scale studies using samples from …

… our understanding of the genetic landscape of multiple myeloma. Several … The life history of
multiple myeloma is characterized by … , copy-number changes, and structural events typical of …

… Multiple myeloma (MM) is the second commonest … 14), copy number changes, and mutations
in RAS/MAPK signalling pathway (eg NRAS) (Figure 1.3)25. A key copy number variation is …

… The timeline of observed activation of mutational processes … Here we were able to extend
our understanding of the mutational … Although translocations and copy number alterations are …

… translocations or chromosome number alterations resulting in … importance of copy number
aberration changes, acquired … decades in the understanding the molecular abnormalities …

… a better understanding of the complex genomic landscape in … copy number alteration
commonly seen in multiple myeloma … to decipher the chronological order in which copy number …