Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria
APOBEC3B, a gene involved in innate response, exhibits insertion–deletion polymorphism
across world populations. We observed the insertion allele to be nearly fixed in malaria
endemic regions of sub-Saharan Africa as well as populations with high malaria incidence
in the past. This prompted us to investigate the possible association of the polymorphism
with falciparum malaria. We studied the distribution of APOBEC3B, in 25 diverse Indian
populations comprising of 500 samples and 176 severe or non-severe Plasmodium …
across world populations. We observed the insertion allele to be nearly fixed in malaria
endemic regions of sub-Saharan Africa as well as populations with high malaria incidence
in the past. This prompted us to investigate the possible association of the polymorphism
with falciparum malaria. We studied the distribution of APOBEC3B, in 25 diverse Indian
populations comprising of 500 samples and 176 severe or non-severe Plasmodium …
Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria.
PJ Pankaj Jha, SS Swapnil Sinha, KK Kanika Kanchan… - 2012 - cabidigitallibrary.org
APOBEC3B, a gene involved in innate response, exhibits insertion-deletion polymorphism
across world populations. We observed the insertion allele to be nearly fixed in malaria
endemic regions of sub-Saharan Africa as well as populations with high malaria incidence
in the past. This prompted us to investigate the possible association of the polymorphism
with falciparum malaria. We studied the distribution of APOBEC3B, in 25 diverse Indian
populations comprising of 500 samples and 176 severe or non-severe Plasmodium …
across world populations. We observed the insertion allele to be nearly fixed in malaria
endemic regions of sub-Saharan Africa as well as populations with high malaria incidence
in the past. This prompted us to investigate the possible association of the polymorphism
with falciparum malaria. We studied the distribution of APOBEC3B, in 25 diverse Indian
populations comprising of 500 samples and 176 severe or non-severe Plasmodium …
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