[HTML][HTML] Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3)
S Mutoh, M Osabe, K Inoue, R Moore… - Journal of Biological …, 2009 - ASBMB
Upon activation by therapeutics, the nuclear xenobiotic/constitutive active/androstane
receptor (CAR) regulates various liver functions ranging from drug metabolism and excretion
to energy metabolism. CAR can also be a risk factor for developing liver diseases such as
hepatocellular carcinoma. Here we have characterized the conserved threonine 38 of
human CAR as the primary residue that regulates nuclear translocation and activation of
CAR. Protein kinase C phosphorylates threonine 38 located on the α-helix spanning from …
receptor (CAR) regulates various liver functions ranging from drug metabolism and excretion
to energy metabolism. CAR can also be a risk factor for developing liver diseases such as
hepatocellular carcinoma. Here we have characterized the conserved threonine 38 of
human CAR as the primary residue that regulates nuclear translocation and activation of
CAR. Protein kinase C phosphorylates threonine 38 located on the α-helix spanning from …
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