Design, synthesis and structure–activity relationships of 3, 5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
Bioorganic & medicinal chemistry letters, 2013•Elsevier
The synthesis and inhibitory potencies of a novel series of 3, 5-diaryl-1H-pyrazoles as
specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The
series is based on hit compound 1 3, 5-diaryl-1H-pyrazole identified from a high-throughout
screen that has been carried out previously and found to inhibit the growth of Mycobacterium
tuberculosis.
specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The
series is based on hit compound 1 3, 5-diaryl-1H-pyrazole identified from a high-throughout
screen that has been carried out previously and found to inhibit the growth of Mycobacterium
tuberculosis.
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果