Determination of cell fate selection during phage lambda infection

F St-Pierre, D Endy - … of the National Academy of Sciences, 2008 - National Acad Sciences
Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes.
For example, some cells lyse whereas others survive as lysogens. A quantitative biophysical
model of lambda infection supports the hypothesis that spontaneous differences in the
timing of individual molecular events during lambda infection leads to variation in the
selection of cell fates. Building from this analysis, the lambda lysis–lysogeny decision now
serves as a paradigm for how intrinsic molecular noise can influence cellular behavior, drive …

Determination of cell fate selection during phage lambda Infection

D Endy, C Kaiser - 2009 - dspace.mit.edu
Bacteriophage lambda infection of Escherichia coli can result in distinct cell fate outcomes:
for example, some cells lyse while others survive as lysogens. A quantitative molecular
model of lambda infection supports the hypothesis that spontaneous differences in the
timing of individual molecular events during lambda infection leads to variation in the
selection of cell fates. Building from this analysis, the lambda lysis-lysogeny decision now
serves as a paradigm for how intrinsic biomolecular noise can influence cellular behavior …
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