Pamidronate d&odium (Fig. 1)) disodium 3-amino-l-hydroxypropylidenebisphosphonate
pentahydrate (APD), is a bisphosphonate that inhibits bone resorption in vivo [11. This
compound is used in the treatment of bone diseases, such as Paget's disease [2] and
hypercalcaemia of malignancy [3, 4].