Ketorolac tromethamine is a member of the pyrrolopyrrole group of non-steroidal abtiinflammatory drug (NSAID) that exhibits analgesic, anti-inflammatory and antipyretic activity. It inhibits the cyclo-oxygenase enzyme system and hence prostaglandin synthesis. It has more pronounced analgesic activity than most NSAIDs. The aim of this work was to prepare and evaluate the ketorolac tromethamine tablets with higher dissolution rates and to compare them with marketed product. Direct compression method was adopted for preparation of tablet using different excipients namely; microcrystalline cellulose, spray dried lactose and starch 1500. The effect of excipients on the drug release from prepared tablets was also studied. All the tablet quality control tests were studied. All formulations showed good mechanical properties and complied with the USP 28 pharmacopeial standard requirements for uniformity of dosage units and friability. Formula No. 2 containing starch 1500 and microcrystalline cellulose gave higher percentage of ketorolac tromethamine release in comparison with other formulations and marketed product.