Background Hypoxia is associated with a poor prognosis in prostate cancer. This work
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate
cancer. Method Hypoxia genes were identified in vitro via RNA-sequencing and combined
with in vivo gene co-expression analysis to generate a signature. The signature was
independently validated in eleven prostate cancer cohorts and a bladder cancer phase III
randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON). Results A …