Development and validation of a novel evaporation setup-assisted TLC method with fluorescence detection for determination of flibanserin in pharmaceutical and …

NM Hosny, M Abdelkarim, MI Gadallah… - … of Chromatography B, 2022 - Elsevier
A specific and sensitive thin layer chromatographic method coupled with fluorescence
detection for determination of flibanserin (FLN) that treats woman hypoactive sexual desire
disorder was developed. The proposed method depends on the enhancement of FLN native
fluorescence intensity via the exposure of the developed TLC plate to concentrated
hydrochloric acid vapors. Herein, an evaporation setup needed for HCl vapors exposure
step was designed for the first time to ensure a uniform distribution of the vapors throughout …
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