[HTML][HTML] Development of a binary carrier system consisting polyethylene glycol 4000-ethyl cellulose for ibuprofen solid dispersion
GSA Alagdar, MK Oo, P Sengupta… - International journal …, 2017 - ncbi.nlm.nih.gov
International journal of pharmaceutical investigation, 2017•ncbi.nlm.nih.gov
Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1: 3.5
w/w)(SD PE). Another SD was prepared using only PEG (SD P) as a carrier for comparative
study. The developed formulation was evaluated using optical microscopy, scanning
electron microscopy (SEM), determination of moisture content, differential scanning
calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform
infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the …
w/w)(SD PE). Another SD was prepared using only PEG (SD P) as a carrier for comparative
study. The developed formulation was evaluated using optical microscopy, scanning
electron microscopy (SEM), determination of moisture content, differential scanning
calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform
infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the …
Methods:
Melt mixing SD method was employed using a ratio of API: binary carrier (1: 3.5 w/w)(SD PE). Another SD was prepared using only PEG (SD P) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties.
Results:
SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which was responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SD PE> SD P> physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SD PE was excellent.
Conclusion:
The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form.
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