[HTML][HTML] Development of a fast SARS-CoV-2 IgG ELISA, based on receptor-binding domain, and its comparative evaluation using temporally segregated samples from …
F Mehdi, S Chattopadhyay, R Thiruvengadam… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 antibody detection assays are crucial for gathering seroepidemiological
information and monitoring the sustainability of antibody response against the virus. The
SARS-CoV-2 Spike protein's receptor-binding domain (RBD) is a very specific target for anti-
SARS-CoV-2 antibodies detection. Moreover, many neutralizing antibodies are mapped to
this domain, linking antibody response to RBD with neutralizing potential. Detection of IgG
antibodies, rather than IgM or total antibodies, against RBD is likely to play a larger role in …
information and monitoring the sustainability of antibody response against the virus. The
SARS-CoV-2 Spike protein's receptor-binding domain (RBD) is a very specific target for anti-
SARS-CoV-2 antibodies detection. Moreover, many neutralizing antibodies are mapped to
this domain, linking antibody response to RBD with neutralizing potential. Detection of IgG
antibodies, rather than IgM or total antibodies, against RBD is likely to play a larger role in …
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