Development of coarse-graining DNA models for single-nucleotide resolution analysis
K Doi, T Haga, H Shintaku… - … Transactions of the …, 2010 - royalsocietypublishing.org
Recently, analytical techniques have been developed for detecting single-nucleotide
polymorphisms in DNA sequences. Improvements of the sequence identification techniques
has attracted much attention in several fields. However, there are many things that have not
been clarified about DNA. In the present study, we have developed a coarse-graining DNA
model with single-nucleotide resolution, in which potential functions for hydrogen bonds and
the π-stack effect are taken into account. Using Langevin-dynamics simulations, several …
polymorphisms in DNA sequences. Improvements of the sequence identification techniques
has attracted much attention in several fields. However, there are many things that have not
been clarified about DNA. In the present study, we have developed a coarse-graining DNA
model with single-nucleotide resolution, in which potential functions for hydrogen bonds and
the π-stack effect are taken into account. Using Langevin-dynamics simulations, several …
[PDF][PDF] Development of coarse-graining DNA models for
K Doi, T Haga, H Shintaku, S Kawano - 2010 - researchgate.net
Recently, analytical techniques have been developed for detecting single-nucleotide
polymorphisms in DNA sequences. Improvements of the sequence identification techniques
has attracted much attention in several fields. However, there are many things that have not
been clarified about DNA. In the present study, we have developed a coarsegraining DNA
model with single-nucleotide resolution, in which potential functions for hydrogen bonds and
the p-stack effect are taken into account. Using Langevin-dynamics simulations, several …
polymorphisms in DNA sequences. Improvements of the sequence identification techniques
has attracted much attention in several fields. However, there are many things that have not
been clarified about DNA. In the present study, we have developed a coarsegraining DNA
model with single-nucleotide resolution, in which potential functions for hydrogen bonds and
the p-stack effect are taken into account. Using Langevin-dynamics simulations, several …
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