Development of diagnostic fragment ion library for glycated peptides of human serum albumin: targeted quantification in prediabetic, diabetic, and microalbuminuria …
AM Korwar, G Vannuruswamy… - Molecular & Cellular …, 2015 - ASBMB
Human serum albumin is one of the most abundant plasma proteins that readily undergoes
glycation, thus glycated albumin has been suggested as an additional marker for monitoring
glycemic status. Hitherto, only Amadori-modified peptides of albumin were quantified. In this
study, we report the construction of fragment ion library for Amadori-modified lysine (AML), N
(ε)-(carboxymethyl) lysine (CML)-, and N (ε)-(carboxyethyl) lysine (CEL)-modified peptides of
the corresponding synthetically modified albumin using high resolution accurate mass …
glycation, thus glycated albumin has been suggested as an additional marker for monitoring
glycemic status. Hitherto, only Amadori-modified peptides of albumin were quantified. In this
study, we report the construction of fragment ion library for Amadori-modified lysine (AML), N
(ε)-(carboxymethyl) lysine (CML)-, and N (ε)-(carboxyethyl) lysine (CEL)-modified peptides of
the corresponding synthetically modified albumin using high resolution accurate mass …
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