Development of optimized novel liposome loaded with 6-gingerol and assessment of its therapeutic activity against NSCLC In vitro and In vivo experimental models
P Thangavelu, V Sundaram, K Gunasekaran… - Chemistry and Physics …, 2022 - Elsevier
Gingerol (Gn) is an active compound derived from ginger which possesses various
biological activities. The therapeutic applications of Gn are limited due to its hydrophobic
nature. To ease its administration, one of the nano-emulsion methods, liposome was
selected to encapsulate Gn. Response Surface Methodology (RSM) was used to optimize
liposome ratio. 97.2% entrapment efficiency was achieved at the ratio of 1: 20: 2 (Drug:
Lipid: Cholesterol). The optimized liposome attained size below 200 d nm, spherical shape …
biological activities. The therapeutic applications of Gn are limited due to its hydrophobic
nature. To ease its administration, one of the nano-emulsion methods, liposome was
selected to encapsulate Gn. Response Surface Methodology (RSM) was used to optimize
liposome ratio. 97.2% entrapment efficiency was achieved at the ratio of 1: 20: 2 (Drug:
Lipid: Cholesterol). The optimized liposome attained size below 200 d nm, spherical shape …
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