Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo [b] fluorene and retene in the zebrafish Danio rerio
This study examined the developmental toxicity of the polycyclic aromatic hydrocarbons
(PAHs) 11H-benzo (b) fluorene (BBF) and 4-azapyrene (AP) in comparison to the known
teratogen retene. Developmental toxicity assays were performed in zebrafish embryos
exposed for 120h. BBF and retene induced a similar dioxin-like phenotype, whereas AP
showed distinct effects, particularly craniofacial malformations. Microarray analysis revealed
that for BBF and retene, drug metabolism pathways were induced, which were confirmed by …
(PAHs) 11H-benzo (b) fluorene (BBF) and 4-azapyrene (AP) in comparison to the known
teratogen retene. Developmental toxicity assays were performed in zebrafish embryos
exposed for 120h. BBF and retene induced a similar dioxin-like phenotype, whereas AP
showed distinct effects, particularly craniofacial malformations. Microarray analysis revealed
that for BBF and retene, drug metabolism pathways were induced, which were confirmed by …
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