Background Hyponatremia is a common electrolyte disorder. Multiple organizations have
published guidance documents to assist clinicians in managing hyponatremia. We aimed to
explore the scope, content, and consistency of these documents. Methods We searched
MEDLINE, EMBASE, and websites of guideline organizations and professional societies to
September 2014 without language restriction for Clinical Practice Guidelines (defined as
any document providing guidance informed by systematic literature review) and Consensus …

Methods: After informed consent or waiver, medical records of pts meeting the registry entry
criteria, principally age ³ 18 years, and euvolemic (US & EU) or hypervolemic (US only) HN
(serum sodium ([Na])≤ 130 mmol/L) were abstracted. Approximately 98% of the planned
5,000 pts have been enrolled. Pt data are summarized by sample size (n) and percentage
(%) for categorical data, and mean±SD for continuous data. Results: A total of 3795 of the
4909 pts enrolled between study initiation in Sept 2010 and Jan 2013 at 160 US and 93 EU …