[HTML][HTML] Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to α2β1 integrin and collagen
I Tanjoni, K Evangelista, MS Della-Casa, D Butera… - Toxicon, 2010 - Elsevier
SVMPs are multi-domain proteolytic enzymes in which disintegrin-like and cysteine-rich
domains bind to cell receptors, plasma or ECM proteins. We have recently reported that
jararhagin, a P-III class SVMP, binds to collagen with high affinity through an epitope located
within the Da-disintegrin sub-domain. In this study, we evaluated the binding of jararhagin to
α2β1 integrin (collagen receptor) using monoclonal antibodies and recombinant jararhagin
fragments. In solid phase assays, binding of jararhagin to α2β1 integrin was detectable from …
domains bind to cell receptors, plasma or ECM proteins. We have recently reported that
jararhagin, a P-III class SVMP, binds to collagen with high affinity through an epitope located
within the Da-disintegrin sub-domain. In this study, we evaluated the binding of jararhagin to
α2β1 integrin (collagen receptor) using monoclonal antibodies and recombinant jararhagin
fragments. In solid phase assays, binding of jararhagin to α2β1 integrin was detectable from …
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