Interleukin‐6 (IL‐6) induces growth arrest and macrophage differentiation through its
receptor in a murine myeloid leukaemic cell line, M1, although it is largely unknown how the
IL‐6 receptor generates these signals. By using chimeric receptors consisting of the
extracellular domain of growth hormone receptor and the transmembrane and cytoplasmic
domain of gp130 with progressive C‐terminal truncations, we showed that the membrane‐
proximal 133, but not 108, amino acids of gp130 could generate the signals for growth …

CiNii 博士論文 - Differentiation and growth arrest signals are generated through the
cytoplasmic region of gp130 that is essential for Stat3 activation … Differentiation and
growth arrest signals are generated through the cytoplasmic region of gp130 that is
essential for Stat3 activation gp130のStat3活性化領域が分化誘導,増殖抑制シグナルを伝達
する … Differentiation and growth arrest signals are generated through the cytoplasmic
region of gp130 that is essential for Stat3 activation …