Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in …

AS de Freitas, VR Funck, M dos Santos Rotta… - Brain Research …, 2009 - Elsevier
Oxidative stress has been pointed out as an important molecular mechanism in
methylmercury (MeHg) intoxication. At low doses, diphenyl diselenide ((PhSe) 2), a
structurally simple organoselenium compound, has been shown to possess antioxidant and
neuroprotective properties. Here we have examined the possible in vivo protective effect of
diphenyl diselenide against the potential pro-oxidative effects of MeHg in mouse liver,
kidney, cerebrum and cerebellum. The effects of MeHg exposure (2mg/(kgday) of …
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