Resistance factors for direct plant defense against herbivorous insects comprise plant traits that negatively affect insect preference (host plant selection, oviposition, feeding behavior) or performance (growth rate, development, reproductive success) resulting in increased plant fitness in a hostile environment. Such traits include morphological features for physical defense, like thorns, spines, and trichomes, epicuticular wax films and wax crystals, tissue toughness, as well as secretory structures and conduits for latices or resins. They also include compounds for chemical defense, like secondary metabolites, digestibility reducing proteins, and antinutritive enzymes. All these traits may be expressed constitutively as preformed resistance factors, or they may be inducible and deployed only after attack by insect herbivores. The induction of defensive traits is not restricted to the site of attack but extends to non-infested healthy parts of the plants. The systemic nature of plant responses to herbivore attack necessitates a long-distance signaling system capable of generating, transporting, and interpreting alarm signals produced at the plant–herbivore interface. Much of the research on the signaling events triggered by herbivory has focused on tomato and other solanaceous plants. In this model system, the peptide systemin acts at or near the wound site to amplify the production of jasmonic acid. Jasmonic acid or its metabolites serve as phloem-mobile long-distance signals, and induce the expression of defense genes in distal parts of the plant. In this chapter, we will provide an overview of physical and chemical defense traits, and review the signaling mechanisms that account for their inducible expression after insect attack.