Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome
RK Agrawal, P Penczek, RA Grassucci, Y Li, AD Leith… - Science, 1996 - science.org
Science, 1996•science.org
Transfer RNA (tRNA) molecules play a crucial role in protein biosynthesis in all organisms.
Their interactions with ribosomes mediate the translation of genetic messages into
polypeptides. Three tRNAs bound to the Escherichia coli 70 S ribosome were visualized
directly with cryoelectron microscopy and three-dimensional reconstruction. The detailed
arrangement of A-and P-site tRNAs inferred from this study allows localization of the sites for
anticodon interaction and peptide bond formation on the ribosome.
Their interactions with ribosomes mediate the translation of genetic messages into
polypeptides. Three tRNAs bound to the Escherichia coli 70 S ribosome were visualized
directly with cryoelectron microscopy and three-dimensional reconstruction. The detailed
arrangement of A-and P-site tRNAs inferred from this study allows localization of the sites for
anticodon interaction and peptide bond formation on the ribosome.
Transfer RNA (tRNA) molecules play a crucial role in protein biosynthesis in all organisms. Their interactions with ribosomes mediate the translation of genetic messages into polypeptides. Three tRNAs bound to the Escherichia coli 70S ribosome were visualized directly with cryoelectron microscopy and three-dimensional reconstruction. The detailed arrangement of A- and P-site tRNAs inferred from this study allows localization of the sites for anticodon interaction and peptide bond formation on the ribosome.
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