Discovery and refinement of loci associated with lipid levels

Nature genetics, 2013 - nature.com
… at P < 5 × 10 −8 , including 62 loci not previously associated with lipid levels in humans. …
signals in 12 loci. We find that loci associated with blood lipid levels are often associated with …

[HTML][HTML] Discovery and refinement of loci associated with lipid levels

CJ Willer, EM Schmidt, S Sengupta, GM Peloso… - Nature …, 2013 - ncbi.nlm.nih.gov
… To identify new loci and refine known loci influencing these lipids, we … 157 loci associated
with lipid levels at P< 5× 10− 8, including 62 loci not previously associated with lipid levels in …

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

V Iotchkova, J Huang, JA Morris, D Jain, C Barbieri… - Nature …, 2016 - nature.com
… and new loci associated with the 20 traits, we resolve the associations of 59 loci to credible
… 1 Mb of a known locus, one was associated with HDL cholesterol levels (an intronic variant …

Novel loci linked to serum lipid traits are identified in a genome-wide association study of a highly admixed Brazilian population-the 2015 ISA Nutrition

JMRS Leite, JL Pereira, C Alves de Souza… - Lipids in Health and …, 2024 - Springer
… and might be connected with hepatic lipidLDL-c, uric acid, and total cholesterol levels [49,
50]. This hypothesis was confirmed in this study, as shown by low, albeit significant LD values

Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association …

ÅK Hedman, MM Mendelson, RE Marioni… - Circulation …, 2017 - Am Heart Assoc
… CpGs associated with lipid levels in the discovery stage … lipid-associated CpGs were enriched
in lipid and amino acid metabolism processes. A differentially methylated locus associated

From lipid locus to drug target through human genomics

SW Van Der Laan, EL Harshfield… - Cardiovascular …, 2018 - academic.oup.com
lipid levels, a number of association studies of major lipidslipids was published in 2010,
which reported the discovery of … resulted in the discovery of eight replicated loci associated with …

Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci

N Zubair, M Graff, J Luis Ambite… - Human molecular …, 2016 - academic.oup.com
… have identified over 150 loci associated with lipid traits, … loci that have low to moderate effects
on lipid levels. Together, these variants explain only 8–10% of the variance in lipid levels, a …

Genome-wide enrichment of m6A-associated single-nucleotide polymorphisms in the lipid loci

X Mo, S Lei, Y Zhang, H Zhang - The pharmacogenomics journal, 2019 - nature.com
… A-SNPs on lipid levels. We examined the association of m 6 A-SNPs with lipid levels in a
genome… Furthermore, we performed expression quantitative trait loci and differential expression …

Genome-wide approaches to finding novel genes for lipid traits: the start of a long road

AC Edmondson, DJ Rader - Circulation: Cardiovascular Genetics, 2008 - Am Heart Assoc
… disease process affects the lipid profile or when a substantial … in newly discovered
associations with LDL-C and HDL-C. … of new genetic loci associated with lipid phenotypes using …

Replication and fine-mapping of genetic predictors of lipid traits in African–Americans

QP Feng, WQ Wei, RT Levinson, JD Mosley… - Journal of human …, 2017 - nature.com
… identified >150 loci associated with concentrations of one or more lipid traits. Nevertheless,
… We manually reviewed charts for individuals having extreme lipid levels to exclude the data …