Discovery and refinement of loci associated with lipid levels
Nature genetics, 2013 - nature.com
… at P < 5 × 10 −8 , including 62 loci not previously associated with lipid levels in humans. …
signals in 12 loci. We find that loci associated with blood lipid levels are often associated with …
signals in 12 loci. We find that loci associated with blood lipid levels are often associated with …
[HTML][HTML] Discovery and refinement of loci associated with lipid levels
… To identify new loci and refine known loci influencing these lipids, we … 157 loci associated
with lipid levels at P< 5× 10− 8, including 62 loci not previously associated with lipid levels in …
with lipid levels at P< 5× 10− 8, including 62 loci not previously associated with lipid levels in …
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
… and new loci associated with the 20 traits, we resolve the associations of 59 loci to credible
… 1 Mb of a known locus, one was associated with HDL cholesterol levels (an intronic variant …
… 1 Mb of a known locus, one was associated with HDL cholesterol levels (an intronic variant …
Novel loci linked to serum lipid traits are identified in a genome-wide association study of a highly admixed Brazilian population-the 2015 ISA Nutrition
JMRS Leite, JL Pereira, C Alves de Souza… - Lipids in Health and …, 2024 - Springer
… and might be connected with hepatic lipid … LDL-c, uric acid, and total cholesterol levels [49,
50]. This hypothesis was confirmed in this study, as shown by low, albeit significant LD values …
50]. This hypothesis was confirmed in this study, as shown by low, albeit significant LD values …
Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association …
… CpGs associated with lipid levels in the discovery stage … lipid-associated CpGs were enriched
in lipid and amino acid metabolism processes. A differentially methylated locus associated …
in lipid and amino acid metabolism processes. A differentially methylated locus associated …
From lipid locus to drug target through human genomics
SW Van Der Laan, EL Harshfield… - Cardiovascular …, 2018 - academic.oup.com
… lipid levels, a number of association studies of major lipids … lipids was published in 2010,
which reported the discovery of … resulted in the discovery of eight replicated loci associated with …
which reported the discovery of … resulted in the discovery of eight replicated loci associated with …
Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci
N Zubair, M Graff, J Luis Ambite… - Human molecular …, 2016 - academic.oup.com
… have identified over 150 loci associated with lipid traits, … loci that have low to moderate effects
on lipid levels. Together, these variants explain only 8–10% of the variance in lipid levels, a …
on lipid levels. Together, these variants explain only 8–10% of the variance in lipid levels, a …
Genome-wide enrichment of m6A-associated single-nucleotide polymorphisms in the lipid loci
X Mo, S Lei, Y Zhang, H Zhang - The pharmacogenomics journal, 2019 - nature.com
… A-SNPs on lipid levels. We examined the association of m 6 A-SNPs with lipid levels in a
genome… Furthermore, we performed expression quantitative trait loci and differential expression …
genome… Furthermore, we performed expression quantitative trait loci and differential expression …
Genome-wide approaches to finding novel genes for lipid traits: the start of a long road
AC Edmondson, DJ Rader - Circulation: Cardiovascular Genetics, 2008 - Am Heart Assoc
… disease process affects the lipid profile or when a substantial … in newly discovered
associations with LDL-C and HDL-C. … of new genetic loci associated with lipid phenotypes using …
associations with LDL-C and HDL-C. … of new genetic loci associated with lipid phenotypes using …
Replication and fine-mapping of genetic predictors of lipid traits in African–Americans
… identified >150 loci associated with concentrations of one or more lipid traits. Nevertheless,
… We manually reviewed charts for individuals having extreme lipid levels to exclude the data …
… We manually reviewed charts for individuals having extreme lipid levels to exclude the data …