… discover an anti-ACE2 peptide that can block the SARS-CoV-2-RBD/ACE2 interaction, thereby
blocking the virus infection (… strategy, which can discover small peptides that only bind to …

… great amount of data making COVID-19 drug discovery an emerging, … of structural data on
SARS CoV-2-RBD/ACE2 interaction, … aim to counteract the SARS-CoV-2 infectivity and, in this …

… discovered ligands, we proceeded to evaluate the activity of peptides 1–7 at inhibiting
SARS-CoV-2 infection of ACE2- … states of the ACE2-2 complexes, which is smaller than that seen …

… ACE2 inhibitors that would prevent infection by both SARS-… amidated peptide, was a
potent ACE2 peptide inhibitor with … to include inhibitor discovery against Ebola and SARS-CoV-2 …

… We envision that this type of short linear peptide will not be stable against proteolysis and,
most significantly, may not have the right secondary structure required for efficient binding with …

… step of SARS-CoV-2 invasion involving S binding to its fusion receptor (ACE2) offers the
possibilities of using soluble ACE2 peptide or … -S peptides to prevent SARS-CoV-2 infection. …

… The mimetic (wild-type, WT) ACE2 peptide significantly inhibited SARS-CoV-2 infection of
… possibility of using a smaller ACE2 alpha-helix α1 peptide encompassing only critical amino …

… S1 promotes virus infection by binding to angiotensin-converting enzyme II (ACE2) of the …
3CLpro inhibitory properties is an established method for discovering new lead compounds. …

… Although the epidemic was relatively small in scale, the virus had … better understanding of
SARS-CoV entry and discovery of a … , peptide P6 potently inhibited SARS pseudovirus infection …

… as highly effective against SARS-CoV-2 infection. The … existing peptide-based antiviral
therapeutics, their discovery methods… S protein of the virus and the ACE2 of the cell. Therefore, the …