Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine inflammatory response
PFKFB3 is a target gene of peroxisome proliferator-activated receptor gamma (PPARγ) and
encodes for inducible 6-phosphofructo-2-kinase (iPFK2). As a key regulatory enzyme that
stimulates glycolysis, PFKFB3/iPFK2 links adipocyte metabolic and inflammatory responses.
Additionally, PFKFB3/iPFK2 is involved in the effect of active PPARγ on suppressing
overnutrition-induced adipose tissue inflammatory response, which accounts for the insulin-
sensitizing and antidiabetic effects of PPARγ activation. Using PFKFB3/iPFK2-disrupted …
encodes for inducible 6-phosphofructo-2-kinase (iPFK2). As a key regulatory enzyme that
stimulates glycolysis, PFKFB3/iPFK2 links adipocyte metabolic and inflammatory responses.
Additionally, PFKFB3/iPFK2 is involved in the effect of active PPARγ on suppressing
overnutrition-induced adipose tissue inflammatory response, which accounts for the insulin-
sensitizing and antidiabetic effects of PPARγ activation. Using PFKFB3/iPFK2-disrupted …
[PDF][PDF] Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine inflammatory response☆
YE Chenc, JM Sturinoa, C Wua - 2012 - pkusz.edu.cn
PFKFB3 is a target gene of peroxisome proliferator-activated receptor gamma (PPARγ) and
encodes for inducible 6-phosphofructo-2-kinase (iPFK2). As a key regulatory enzyme that
stimulates glycolysis, PFKFB3/iPFK2 links adipocyte metabolic and inflammatory responses.
Additionally, PFKFB3/iPFK2 is involved in the effect of active PPARγ on suppressing
overnutrition-induced adipose tissue inflammatory response, which accounts for the insulin-
sensitizing and antidiabetic effects of PPARγ activation. Using PFKFB3/iPFK2-disrupted …
encodes for inducible 6-phosphofructo-2-kinase (iPFK2). As a key regulatory enzyme that
stimulates glycolysis, PFKFB3/iPFK2 links adipocyte metabolic and inflammatory responses.
Additionally, PFKFB3/iPFK2 is involved in the effect of active PPARγ on suppressing
overnutrition-induced adipose tissue inflammatory response, which accounts for the insulin-
sensitizing and antidiabetic effects of PPARγ activation. Using PFKFB3/iPFK2-disrupted …
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