Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality
S Maciejewski, TJ Ruckwardt, KM Morabito… - Science translational …, 2020 - science.org
The emergence of Zika virus (ZIKV) in the Americas stimulated the development of multiple
ZIKV vaccine candidates. We previously developed two related DNA vaccine candidates
encoding ZIKV structural proteins that were immunogenic in animal models and humans.
We sought to identify neutralizing antibody (NAb) properties induced by each vaccine that
correlated with protection in nonhuman primates (NHPs). Despite eliciting equivalent NAb
titers in NHPs, these vaccines were not equally protective. The transfer of equivalent titers of …
ZIKV vaccine candidates. We previously developed two related DNA vaccine candidates
encoding ZIKV structural proteins that were immunogenic in animal models and humans.
We sought to identify neutralizing antibody (NAb) properties induced by each vaccine that
correlated with protection in nonhuman primates (NHPs). Despite eliciting equivalent NAb
titers in NHPs, these vaccines were not equally protective. The transfer of equivalent titers of …
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