Dialysis patients display a high cardiovascular mortality, the causes of which are still not
completely explained, but are related to uremic toxicity. Among uremic toxins, homocysteine
and cysteine are both substrates of cystathionine β-synthase and cystathionine γ-lyase in
hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine
and homolanthionine, considered stable indirect biomarkers of its production. Hydrogen
sulfide is involved in the modulation of multiple pathophysiological responses. In uremia, we …