Does Early Response Predict Subsequent Remission in Bipolar Depression Treated with
Three Cycles of Total Sleep Deprivation Combined with Light Therapy and Lithium? …
Does Early Response Predict Subsequent Remission in Bipolar Depression Treated with
Three Cycles of Total Sleep Deprivation Combined with Light Therapy and Lithium? …

Background The combination of three cycles of sleep deprivation (SD), light therapy (LT),
and lithium has recently been proposed as a possible first-line treatment for bipolar
depression. However, it is unclear whether early improvement predicts final
response/remission in bipolar depression treated with this regimen. Method We studied 220
consecutively admitted inpatients with a major depressive episode in the course of bipolar
disorder. The relation between response to first SD and response/remission at the end of the …