Double dehydrogenation of primary amines to nitriles by a ruthenium complex featuring pyrazole functionality
Journal of the American Chemical Society, 2018•ACS Publications
A ruthenium (II) complex bearing a naphthyridine-functionalized pyrazole ligand catalyzes
oxidant-free and acceptorless selective double dehydrogenation of primary amines to
nitriles at moderate temperature. The role of the proton-responsive entity on the ligand
scaffold is demonstrated by control experiments, including the use of a N-methylated
pyrazole analogue. DFT calculations reveal intricate hydride and proton transfers to achieve
the overall elimination of 2 equiv of H2.
oxidant-free and acceptorless selective double dehydrogenation of primary amines to
nitriles at moderate temperature. The role of the proton-responsive entity on the ligand
scaffold is demonstrated by control experiments, including the use of a N-methylated
pyrazole analogue. DFT calculations reveal intricate hydride and proton transfers to achieve
the overall elimination of 2 equiv of H2.
A ruthenium(II) complex bearing a naphthyridine-functionalized pyrazole ligand catalyzes oxidant-free and acceptorless selective double dehydrogenation of primary amines to nitriles at moderate temperature. The role of the proton-responsive entity on the ligand scaffold is demonstrated by control experiments, including the use of a N-methylated pyrazole analogue. DFT calculations reveal intricate hydride and proton transfers to achieve the overall elimination of 2 equiv of H2.
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