Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network
V Parra, F Altamirano, CP Hernández-Fuentes… - Circulation …, 2018 - Am Heart Assoc
Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-
activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is
located on chromosome 21 in proximity to the Down syndrome critical region. The hearts
and brains of Rcan1 KO mice are more susceptible to damage from ischemia/reperfusion
(I/R); however, the underlying cause is not known. Objective: Mitochondria are key
mediators of I/R damage. The goal of these studies was to determine the impact of RCAN1 …
activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is
located on chromosome 21 in proximity to the Down syndrome critical region. The hearts
and brains of Rcan1 KO mice are more susceptible to damage from ischemia/reperfusion
(I/R); however, the underlying cause is not known. Objective: Mitochondria are key
mediators of I/R damage. The goal of these studies was to determine the impact of RCAN1 …
Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network
MV Parra Ortíz, F Altamirano, C Hernández Fuentes… - 2018 - repositorio.uchile.cl
Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-
activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is
located on chromosome 21 in proximity to the Down syndrome critical region. The hearts
and brains of Rcan1 KO mice are more susceptible to damage from ischemia/reperfusion
(I/R); however, the underlying cause is not known. Objective: Mitochondria are key
mediators of I/R damage. The goal of these studies was to determine the impact of RCAN1 …
activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is
located on chromosome 21 in proximity to the Down syndrome critical region. The hearts
and brains of Rcan1 KO mice are more susceptible to damage from ischemia/reperfusion
(I/R); however, the underlying cause is not known. Objective: Mitochondria are key
mediators of I/R damage. The goal of these studies was to determine the impact of RCAN1 …
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