Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post kala-azar dermal leishmaniasis
V Bhandari, A Kulshrestha, DK Deep… - PLoS neglected …, 2012 - journals.plos.org
… cases recruited for MIL treatment, we observed comparable drug susceptibility in pre- and
post-treatment isolates … while MIL susceptibility was significantly reduced in isolates from VL …
post-treatment isolates … while MIL susceptibility was significantly reduced in isolates from VL …
[HTML][HTML] In vitro susceptibility of Leishmania donovani to miltefosine in Indian visceral leishmaniasis
VK Prajapati, S Sharma, M Rai, B Ostyn… - The American journal …, 2013 - ncbi.nlm.nih.gov
… was performed on Leishmania donovani isolates from Indian … In that study, drug susceptibility
testing was done with … of parasite susceptibility to MIL (before and after treatment) on MIL-…
testing was done with … of parasite susceptibility to MIL (before and after treatment) on MIL-…
Laboratory confirmed miltefosine resistant cases of visceral leishmaniasis from India
… The in vitro drug susceptibility assays carried out on both isolates showed good IC 50 … case
of VL was reported from Nepal with clinical relapse after successful treatment with miltefosine…
of VL was reported from Nepal with clinical relapse after successful treatment with miltefosine…
Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain
… susceptibility, warranting a reassessment of our current view on treatment failure and
drug resistance in leishmaniasis … promastigote susceptibility of strains isolated from MIL-treated …
drug resistance in leishmaniasis … promastigote susceptibility of strains isolated from MIL-treated …
Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations
B Monge-Maillo, R López-Vélez - Clinical Infectious Diseases, 2015 - academic.oup.com
… of VL within 6 months after miltefosine treatment, with relapse … of drug resistance and
increase treatment efficacy; and it … rate of <70%, probably due to the high proportion of isolated …
increase treatment efficacy; and it … rate of <70%, probably due to the high proportion of isolated …
Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure
TPC Dorlo, S Rijal, B Ostyn, PJ de Vries… - The Journal of …, 2014 - academic.oup.com
… , approximately at day 28 after the start of miltefosine treatment. Samples were kept frozen
… with intracellular drug susceptibility testing of available clinical Leishmania isolates from this …
… with intracellular drug susceptibility testing of available clinical Leishmania isolates from this …
Drug resistance in visceral leishmaniasis
HC Maltezou - BioMed Research International, 2010 - Wiley Online Library
… among clinical leishmanial isolates. However, the … followed by miltefosine for 7 days (group
E; 45 patients); in this study, similar final cure rates (91%–98%) were noted in all treatment …
E; 45 patients); in this study, similar final cure rates (91%–98%) were noted in all treatment …
Treatment failure and miltefosine susceptibility in dermal leishmaniasis caused by Leishmania subgenus Viannia species
R Obonaga, OL Fernández, L Valderrama… - Antimicrobial agents …, 2014 - Am Soc Microbiol
… Prospective evaluation of drug susceptibility of strains isolated from individual … isolated from
visceral leishmaniasis and PKDL patients who relapsed following miltefosine treatment were …
visceral leishmaniasis and PKDL patients who relapsed following miltefosine treatment were …
Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use
… for monitoring treatment outcomes and drug resistance (if any… that direct testing of isolates
for miltefosine resistance was not … proof of a change in outcome due to miltefosine resistance. …
for miltefosine resistance was not … proof of a change in outcome due to miltefosine resistance. …
The preclinical discovery and development of oral miltefosine for the treatment of visceral leishmaniasis: a case history
JQ Reimao, DP Pita Pedro… - Expert Opinion on Drug …, 2020 - Taylor & Francis
… A decrease in MF susceptibility was also found in clinical isolates of L. … resistance of the
parasites after MF treatment [Citation113] and others factors unrelated to drug resistance may be …
parasites after MF treatment [Citation113] and others factors unrelated to drug resistance may be …