Drug-free ROS sponge polymeric microspheres reduce tissue damage from ischemic and mechanical injury
The inherent antioxidant function of poly (propylene sulfide)(PPS) microspheres (MS) was
dissected for different reactive oxygen species (ROS), and therapeutic benefits of PPS-MS
were explored in models of diabetic peripheral arterial disease (PAD) and mechanically
induced post-traumatic osteoarthritis (PTOA). PPS-MS (∼ 1 μm diameter) significantly
scavenged hydrogen peroxide (H2O2), hypochlorite, and peroxynitrite but not superoxide in
vitro in cell-free and cell-based assays. Elevated ROS levels (specifically H2O2) were …
dissected for different reactive oxygen species (ROS), and therapeutic benefits of PPS-MS
were explored in models of diabetic peripheral arterial disease (PAD) and mechanically
induced post-traumatic osteoarthritis (PTOA). PPS-MS (∼ 1 μm diameter) significantly
scavenged hydrogen peroxide (H2O2), hypochlorite, and peroxynitrite but not superoxide in
vitro in cell-free and cell-based assays. Elevated ROS levels (specifically H2O2) were …
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