Dual CXCR4 and E-selectin inhibitor, GMI-1359, shows anti-bone metastatic effects and synergizes with docetaxel in prostate cancer cell intraosseous growth
Metastatic castration resistant prostate cancer (mCRPC) relapses due to acquired resistance
to docetaxel-based chemotherapy and remains a major threat to patient survival. In this
report, we tested the effectiveness of a dual CXCR4/E-selectin antagonist, GM-I1359, in vitro
and in vivo, as a single agent or in combination with docetaxel (DTX). This agent was
compared to the single CXCR4 antagonist, CTCE-9908, and E-selectin antagonist, GMI-
1271. Here we demonstrate that CXCR4 antagonism reduced growth and enhanced DTX …
to docetaxel-based chemotherapy and remains a major threat to patient survival. In this
report, we tested the effectiveness of a dual CXCR4/E-selectin antagonist, GM-I1359, in vitro
and in vivo, as a single agent or in combination with docetaxel (DTX). This agent was
compared to the single CXCR4 antagonist, CTCE-9908, and E-selectin antagonist, GMI-
1271. Here we demonstrate that CXCR4 antagonism reduced growth and enhanced DTX …
Article Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous …
Metastatic castration resistant prostate cancer (mCRPC) relapses due to acquired resistance
to docetaxel-based chemotherapy and remains a major threat to patient survival. In this
report, we tested the effectiveness of a dual CXCR4/E-selectin antagonist, GM-I1359, in vitro
and in vivo, as a single agent or in combination with docetaxel (DTX). This agent was
compared to the single CXCR4 antagonist, CTCE-9908, and E-selectin antagonist, GMI-
1271. Here we demonstrate that CXCR4 antagonism reduced growth and enhanced DTX …
to docetaxel-based chemotherapy and remains a major threat to patient survival. In this
report, we tested the effectiveness of a dual CXCR4/E-selectin antagonist, GM-I1359, in vitro
and in vivo, as a single agent or in combination with docetaxel (DTX). This agent was
compared to the single CXCR4 antagonist, CTCE-9908, and E-selectin antagonist, GMI-
1271. Here we demonstrate that CXCR4 antagonism reduced growth and enhanced DTX …
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