[PDF][PDF] Dyslipidemic effect of doxorubicin and etoposide: a predisposing factor for the antineoplastic drugs-induced cardiovascular diseases
Research & Reviews: Journal of Pharmacology and Toxicological Studies, 2018•academia.edu
Antineoplastic drugs are well known for their abilities to induce varying degrees of toxicities
and predispose to cardiovascular related disease states. This study, therefore evaluates the
effects of Doxorubicin (Dox)(3 mg/kg body weight) and Etoposide (Etop)(3 mg/kg body
weight) alone and in combinations at 12 and 24 h intervals on plasma lipid profiles and
paraoxonase-1. Lipid peroxidation, superoxide dismutase (SOD), glutathione peroxidase
(Gpx) and reduced glutathione (GSH) in selected male rat organs were also evaluated. The …
and predispose to cardiovascular related disease states. This study, therefore evaluates the
effects of Doxorubicin (Dox)(3 mg/kg body weight) and Etoposide (Etop)(3 mg/kg body
weight) alone and in combinations at 12 and 24 h intervals on plasma lipid profiles and
paraoxonase-1. Lipid peroxidation, superoxide dismutase (SOD), glutathione peroxidase
(Gpx) and reduced glutathione (GSH) in selected male rat organs were also evaluated. The …
Abstract
Antineoplastic drugs are well known for their abilities to induce varying degrees of toxicities and predispose to cardiovascular related disease states.
This study, therefore evaluates the effects of Doxorubicin (Dox)(3 mg/kg body weight) and Etoposide (Etop)(3 mg/kg body weight) alone and in combinations at 12 and 24 h intervals on plasma lipid profiles and paraoxonase-1. Lipid peroxidation, superoxide dismutase (SOD), glutathione peroxidase (Gpx) and reduced glutathione (GSH) in selected male rat organs were also evaluated. The results were analyzed using One-way ANOVA followed by post hoc tests.
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