[HTML][HTML] Dysregulation of the epigenome in human breast cancer: contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the …
R Sandhu, JD Roll, AG Rivenbark… - The American journal of …, 2015 - Elsevier
Triple-negative breast cancers (including basal-like and claudin-low molecular subtypes)
represent 20% to 25% of all breast cancers, but disproportionately contribute to breast
cancer–associated death. We have identified a novel fundamental biological property of
triple-negative breast cancers: most triple-negative breast cancers express aberrant DNA
hypermethylation due to overexpression of DNA methyltransferase 3b (and hyperactivity of
the DNA methyltransferase enzymes). DNA methyltransferase 3b overexpression occurs …
represent 20% to 25% of all breast cancers, but disproportionately contribute to breast
cancer–associated death. We have identified a novel fundamental biological property of
triple-negative breast cancers: most triple-negative breast cancers express aberrant DNA
hypermethylation due to overexpression of DNA methyltransferase 3b (and hyperactivity of
the DNA methyltransferase enzymes). DNA methyltransferase 3b overexpression occurs …
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