Background Cardiac allograft vasculopathy (CAV) remains a leading cause of morbidity and
mortality after orthotopic heart transplantation (OHT). Little is known about the influence of
aspirin on clinical expression of CAV. Methods We followed 120 patients with OHT at a
single center for a median of 7 years and categorized them by the presence or absence of
early aspirin therapy post-transplant (aspirin treatment≥ 6 months in the first year). The
association between aspirin use and time to the primary end-point of angiographic moderate …

Background Cardiac allograft vasculopathy (CAV) remains a leading cause of graft loss in
pediatric heart transplant (HTx) recipients. Adult literature suggests that aspirin (ASA) use in
the early post-HTx period may reduce the risk of CAV. This study aimed to determine the
impact of early ASA use on the development of CAV in pediatric HTx recipients. Methods All
subjects< 17 years of age at time of primary HTx who survived≥ 3 years without evidence of
CAV were identified for inclusion from the Pediatric Heart Transplant Society database …