Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants
A Varvarigou, CL Bardin, K Beharry, S Chemtob… - Jama, 1996 - jamanetwork.com
Objective.—To test whether early postnatal (0 to 3 hours) intravenous administration of
ibuprofen will prevent patent ductus arteriosus (PDA) in preterm neonates. Design.—
Prospective sequential controlled trial with three treatment arms. Setting.—Level 3 perinatal-
neonatal intensive care nursery. Patients.—Thirty-four premature newborn infants born from
February to August 1993 with a mean birth weight of 913 g (range, 565 to 1460 g) and
gestational age of 26.9 weeks (range, 22.4 to 31.0). Intervention.—Infants were …
ibuprofen will prevent patent ductus arteriosus (PDA) in preterm neonates. Design.—
Prospective sequential controlled trial with three treatment arms. Setting.—Level 3 perinatal-
neonatal intensive care nursery. Patients.—Thirty-four premature newborn infants born from
February to August 1993 with a mean birth weight of 913 g (range, 565 to 1460 g) and
gestational age of 26.9 weeks (range, 22.4 to 31.0). Intervention.—Infants were …
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