[HTML][HTML] Early progression of disease in HIV-infected infants with thymus dysfunction
AP Kourtis, C Ibegbu, AJ Nahmias… - … England Journal of …, 1996 - Mass Medical Soc
Background Infants with congenital thymic deficiency (the DiGeorge syndrome) have
immunodeficiency and a characteristic pattern of low CD4+ and CD8+ T-lymphocyte counts
and low CD5+ B-lymphocyte counts. Because the thymus is essential for the generation of
CD4+ cells, we sought evidence of thymus dysfunction in infants infected perinatally with the
human immunodeficiency virus (HIV). Methods We studied the immunophenotypes of 59
infants with maternally transmitted HIV, 5 infants with the DiGeorge syndrome, and 168 …
immunodeficiency and a characteristic pattern of low CD4+ and CD8+ T-lymphocyte counts
and low CD5+ B-lymphocyte counts. Because the thymus is essential for the generation of
CD4+ cells, we sought evidence of thymus dysfunction in infants infected perinatally with the
human immunodeficiency virus (HIV). Methods We studied the immunophenotypes of 59
infants with maternally transmitted HIV, 5 infants with the DiGeorge syndrome, and 168 …
Early progression of disease in HIV-infected infants with thymus dysfunction
AP Kourtis, C Ibegbu, AJ Nahmias, FK Lee… - International Journal of …, 1997 - elibrary.ru
BACKGROUND: Infants with congenital thymic deficiency (the DiGeorge syndrome) have
immunodeficiency and a characteristic pattern of low CD4+ and CD8+ T-lymphocyte counts
and low CD5+ B-lymphocyte counts. Because the thymus is essential for the generation of
CD4+ cells, we sought evidence of thymus dysfunction in infants infected perinatally with the
human immunodeficiency virus (HIV). METHODS: We studied the immunophenotypes of 59
infants with maternally transmitted HIV, 5 infants with the DiGeorge syndrome, and 168 …
immunodeficiency and a characteristic pattern of low CD4+ and CD8+ T-lymphocyte counts
and low CD5+ B-lymphocyte counts. Because the thymus is essential for the generation of
CD4+ cells, we sought evidence of thymus dysfunction in infants infected perinatally with the
human immunodeficiency virus (HIV). METHODS: We studied the immunophenotypes of 59
infants with maternally transmitted HIV, 5 infants with the DiGeorge syndrome, and 168 …
