Effect of antidepressant switching vs augmentation on remission among patients with major depressive disorder unresponsive to antidepressant treatment: the VAST …
Importance Less than one-third of patients with major depressive disorder (MDD) achieve
remission with their first antidepressant. Objective To determine the relative effectiveness
and safety of 3 common alternate treatments for MDD. Design, Setting, and Participants
From December 2012 to May 2015, 1522 patients at 35 US Veterans Health Administration
medical centers who were diagnosed with nonpsychotic MDD, unresponsive to at least 1
antidepressant course meeting minimal standards for treatment dose and duration …
remission with their first antidepressant. Objective To determine the relative effectiveness
and safety of 3 common alternate treatments for MDD. Design, Setting, and Participants
From December 2012 to May 2015, 1522 patients at 35 US Veterans Health Administration
medical centers who were diagnosed with nonpsychotic MDD, unresponsive to at least 1
antidepressant course meeting minimal standards for treatment dose and duration …
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