Effect of artemether alone and in combination with grapefruit juice on hepatic drug-metabolising enzymes and biochemical aspects in experimental Schistosoma …
NM El-Lakkany, SHS el-Din, AA Badawy… - International journal for …, 2004 - Elsevier
Artemether is an efficacious antimalarial drug that also displays antischistosomal properties.
Grapefruit juice increases the oral availability of a variety of the CYP3A4 substrates. This
study was designed to evaluate the effect of repeated administration of grapefruit juice with
artemether on the hepatic activities of cytochrome P-450 (CYP450) and cytochrome b5 (cyt
b5), on the serum levels of some biochemical enzymes and antischistosome efficacy.
Results showed that administration of grapefruit juice alone induced more inhibition in the …
Grapefruit juice increases the oral availability of a variety of the CYP3A4 substrates. This
study was designed to evaluate the effect of repeated administration of grapefruit juice with
artemether on the hepatic activities of cytochrome P-450 (CYP450) and cytochrome b5 (cyt
b5), on the serum levels of some biochemical enzymes and antischistosome efficacy.
Results showed that administration of grapefruit juice alone induced more inhibition in the …
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