The effects of various levels of dehydration induced by water deprivation were studied in six
Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5
mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water
deprivation, the elimination rate constant of the drug was significantly decreased (P< 0.01)
and the total body clearance was significantly slower (P< 0.001). No statistically significant
changes were observed in the pharmacokinetic parameters describing the distribution of the …