Honey and Moringa leaf extract was known to have potent antioxidant activity that can prevent oxidative stress and DNA damage and repair hematologic status including in pregnant women who exposed to smoke in their environment. The purpose of this study was to know the effect of providing natural antioxidants (honey+ Moringa leaf extract) against oxidative stress and DNA damage in pregnant women who become passive smokers. This study used a non-randomized group pre-post test design with a sample of passive smokers are pregnant women who live in Takalar regency, province of South Sulawesi. 80 samples were third trimester pregnant women who participated in the study and selected by purposive sampling. The samples were divided into two treatment groups ie groups MK who consume honey+ Moringa leaf extract and K groups that only consume Moringa leaf extract in 90 days. Before and after the intervention both groups were measured Malondealdehyde (MDA) and 8-hydroxy-2'deoxyguanosine (8-OHdG) using the ELISA test.